Modo had lost all three head-to-head meetings against Luleå this season, the most recent being on Wednesday when Norrbotninga won 5-0.
In Friday's home game, Modo star Jennifer Wakefield, third in SDHL's shooting league, was missing, but the Angermenlanders still got off to a good start.
Wilma Sundin headed in 1-0 on the cross after just five minutes, on a nice play from Taylor Wabick.
The turning point came between 11.47 and 15.50 in the first period when Luleå scored three quick goals through Jenni Hiirikoski, Sara Lindqvist and Lisa Johansson.
Only 31 seconds took between 2-1 and 3-1.
- It was the three goals in the first that we lost today.
I am terribly disappointed in myself today.
I should have a supporting role in this team, but I don't have that today.
I have an "A" on my chest and then you have to show it on the ice too, says Lina Ljungbom to C More.
"Slopped quite a lot"
In the second period, Modo - who has the best power play of the series - had a frame hit and failed to capitalize on their opportunities despite several numerical superiority.
- I was sloppy quite a lot, but maybe we didn't create the traffic that we should have done to get the puck in when we do shoot.
We have to practice it, says Ljungbom, who was hard on himself in the interview.
The home team did what they could and took out the goalkeeper at the end in a last-ditch effort.
Petra Nieminen was then able to determine the final score 4-1 in an empty net.
The victory is Luleå's fourth straight against Modo this season.
Luleå tops the SDHL on 77 points, eleven more than runner-up Brynäs, who have played one match less.
Modo is four.