The English champions Manchester City surprisingly failed in the quarter-finals of the League Cup at FC Southampton.
Without stars like Erling Haaland and Kevin de Bruyne, but with national player Ilkay Gündogan as captain in the starting XI, Pep Guardiola's team lost 0-2 (0-2) at the bottom of the Premier League.
Nottingham Forest are through to the semi-finals for the first time since 1992, beating Wolverhampton Wanderers 4-3 on penalties.
Manchester City, who have won the League Cup six times in the past nine years, started without Haaland, de Bruyne, Bernardo Silva and Riyad Mahrez.
The penalty quickly followed as Sekou Mara (23) and Moussa Djenepo (28) scored for Southampton, who have been unbeaten in the league since 19 October.
After the break, de Bruyne and later Haaland came, but the turnaround was no longer successful.
In Nottingham it was 1-1 (1-0) after 90 minutes.
Willy Boly (18') put the hosts ahead against his former club before Raul Jimenez (64') equalised.
In the penalty shoot-out, Nottingham kept their nerve.
Forest last reached the semi-finals 31 years ago under legendary coach Brian Clough.
On Tuesday, Manchester United and Newcastle United had already reached the semi-finals, played in the first and second leg at the end of January.
The final will take place at Wembley Stadium in London on February 26.
The winner of the EFL Cup will receive a place in the Europa League next season.