The game at the Gazprom Arena stadium ended with a score of 3:1 in favor of Sergei Semak's wards.
As part of the St. Petersburg club, goals were scored by Malcolm (15th minute), Wendel (65th), Daler Kuzyaev (77th).
At "Rostov" Nikolay Komlichenko scored (47th).
Zenit has 29 points to its credit and takes first place in the standings of the Russian championship.
Rostov is in second place with 22 points.
Earlier: midfielder Andrey Mostovoy was recognized as the best player of Zenit in September according to the fans.