The 22-time Grand Slam winner in the third round match inflicted a crushing defeat on the Italian Lorenzo Sonego in three sets with a score of 6:1, 6:2, 6:4.
The game lasted two hours and seven minutes.
Nadal's next opponent will be Botik van de Zandshulp from the Netherlands.
The total prize fund of the tournament amounted to about £40 million.
Earlier it was reported that Iga Sviontek was defeated by the 37th racket of the world and flew out of Wimbledon.