The meeting was held at the Ceramics - El Madrigal stadium in Villarreal and ended with a score of 3: 2 in favor of the guests.
Goals for Liverpool were scored by Fabinho (62nd), Luis Diaz (67th) and Sadio Mane (75th).
Boulaye Dia (3rd minute) and Francis Coquelin (41st) scored for Unai Emery's team.
Recall that the return semi-final match of the Champions League between Real Madrid and Manchester City will take place on May 4 at 22:00 Moscow time.
Earlier, the head coach of the Spanish "Real" Carlo Ancelotti did not rule out that he would end his career in club football after the end of the contract with the Madrid club.