It was last in December that teams like Dynamo Kyiv and Shakhtar Donetsk played matches in the Ukrainian Premier League.
First the league had its usual winter break, then Ukraine was invaded by Russia in February and the league could not start as planned.
Now the league management together with the clubs and the Ukrainian Football Association have agreed to cancel the rest of the season.
"The football clubs of the Ukrainian Premier League supported the proposal to cancel the 2021/2022 season ... because the tournament cannot be completed due to the extent of the security situation in Ukraine," the league wrote in a statement.
The table position from 24 February will remain as the result of the season, but no champion will be appointed.
However, the two top teams, Shakhtar Donetsk and Dynamo Diev, get the Champions League places.