Barcelona, who had crashed in Spanish professional football, defeated leaders Real Madrid 4-0.
Transfer student Aubameyang held a one-man show.
Barcelona's Aubameyang overtook Real Madrid by clearing Messi's vacancy.
He opened the scoring with his head in the 29th minute of the first half, and
in the second minute, while driving the ball, he helped Ferran Torres score an additional goal with a sensational heel pass.
And 4 minutes later, he led a 4-0 victory with a chip shot that passed the goalkeeper like Messi.
Barcelona have beaten Real Madrid for the first time in three years.
Aubameyang scored 9 goals in 11 matches after the transfer, and Barcelona, who had fallen without Messi, went on to win 5 in a row and jump to third place in the league.