Coach Ralf Rangnick has suffered another setback with Manchester United in the Premier League.
Without the highly decorated football professional Cristiano Ronaldo, the English football record champion lost the prestigious city derby at leaders Manchester City 1: 4 (1: 2) on Sunday.
After just two wins from their last six league games, Manchester United are increasingly concerned about qualifying for the Champions League.
The outstanding performance of Kevin De Bruyne (5th/28th minute) and Riyad Mahrez (68th/90th), each with two goals, ensured the deserved home win for Manchester City, who are led by coach Pep Guardiola.
Former Dortmund player Jadon Sancho scored to equalize for Man United, who were without two strikers through injury.
In addition to Ronaldo, for whom 19-year-old Anthony Elange was in the starting XI, Edinson Cavani was also absent from the Manchester United squad.
United fell to fifth in the table on Sunday, overtaken by Arsenal, who won 3-2 at Watford.
Arsenal have one point more than Ralf Rangnick's side and three games fewer.
Leaders Manchester City have restored their six-point lead over second-placed Liverpool, but have played a game more and will meet their pursuers head-to-head in April.
Jürgen Klopp's Liverpool FC team beat pursuers West Ham United 1-0 (1-0) in an intense game on Saturday.
Sadio Mane (27th) scored after a nice pass from Trent Alexander-Arnold.
Previously, former Leipzig coach Jesse Marsch suffered a defeat on his debut as Leeds United manager.
The 48-year-old lost 0-1 (0-0) with Leeds at Leicester City.