The game, which took place in Melbourne, ended with a score of 2:6, 6:7, 6:4, 6:4, 7:5 in favor of the Spanish tennis player.
The game lasted 5 hours and 24 minutes.
Medvedev and Nadal played the longest match in the history of the Australian Open.
This meeting rose to second place in the list of the longest Grand Slam finals in history.
The 25-year-old Russian Russian several times during the match turned to the referee with a request to calm the fans, who interfered with him by shouting during his innings.
Medvedev is second in the ATP rankings, Nadal is fifth.
Earlier, a video of the joyful reaction of the fans to Medvedev's mistake in the AO final with Nadal appeared.