The meeting ended with the victory of the Spaniard with a score of 6:3, 6:2, 2:6, 6:1.
The match lasted 2 hours 51 minutes.
In the next round of the tournament, Nadal will meet the winner of the confrontation between the Frenchman Adrian Mannarino and another Russian, Aslan Karatsev.
Earlier it was reported that Khachanov won a set against Nadal at the Australian Open.