The game, which took place in Yaroslavl, ended with a score of 3: 2 in favor of the team from the banks of the Volga.
As part of the railwaymen, the goals were scored by Denis Alekseev (4th minute), Artyom Ilyenko (5th) and Artur Kayumov (60th).
Korban Knight (1st) and Sergei Tolchinsky (30th) scored at Avangard.
Lokomotiv (47 points) ranks sixth in the Western Conference standings.
Avangard (44) is in fifth position in the East.
Earlier it was reported that SKA won the fourth consecutive victory in the KHL championship.