The meeting, which took place at the Tottenham stadium in London, ended with a score of 3: 0 in favor of the guests.
The goals scored were Cristiano Ronaldo, Edinson Cavani and Marcus Rashford.
Manchester United scored 17 points and moved up to fifth place.
Tottenham have 15 points and are in eighth.
Earlier, Pogba reacted sharply to media reports about the conflict with Solskjaer.