"Yes, he will play because he got a place in the main tournament," agent Marijn Bal told SVT Sport.
The top-seeded Medvedev jumps off after his body has become too worn out after intense competition, something that has become a habit for the diligently competing Russian at this time of year.
- It is always special to play in front of Russian fans, but this year's calendar has been extremely tough.
I feel that my body is no longer one hundred percent and I am forced to make this tough decision to be able to end this season strongly, says Medvedev, according to the organizer.
Medvedev won his first Grand Slam title when he won the US Open last month after an impressive effort in the final against world setter Novak Djokovic, who had the chance to become the first men's player to reach 21 Grand Slam titles.
Mikael Ymer is ranked 88th in the world and recently declined to wildcard in the Stockholm Open in a couple of weeks.
Top seeded in Moscow will now be the Russian Andrei Rublev, fifth in the world rankings.
Agent Bal does not want to comment on the reason for Mikael Ymer's resignation in the Stockholm Open.
The draw for the main tournament has not yet been published as there have been several late dropouts.
During the weekend, the qualifier will be decided, where big brother Elias Ymer participates.