The 22-year-old leads the race 5 minutes and 20 seconds ahead of runner-up Jonas Vingegaard, Denmark, and seven minutes ahead of runner-up Richard Carapaz, Ecuador, ahead of Sunday's 21st and final stage.
- I'm so happy it's coming to an end.
What a demanding three weeks it has been.
I was not so motivated last night and needed to get started, says Pogacar.
The big favorite has delivered all the time, but also benefited from the fact that compatriot and worst rival Primoz Roglic withdrew due to pain after a previous crash.
Also 2018 winner Geraint Thomas and 2020 Giro d'Italia winner Tao Geoghegan have fallen off the top after crashes.
Now Pogacar does not have to do much more than stay in the group to become the youngest ever to take home two straight Tour de France titles.