Japanese star Ohtani became the winning pitcher, setting the record for the first two-hit start in Major League Baseball's All-Star Game history.
Hyun-Jin Ryu's colleague Guerrero was named MVP with a powerful home run.
Ohtani came out as the number 1 designated hitter and starting pitcher, and was perfect on the mound.
He became a winning pitcher by throwing a fastball with a maximum speed of 161 km/h and hitting all three batters in the first inning.
But both times at bat, it was only an infield ground ball.
Guerrero Jr., who is competing with Ohtani for American League MVP, showed off his might.
In the 3rd inning, he fired a super-large solo cannon with a distance of 142m that flew to the outfield billboard, and National League shortstop Tatis Jr., who was being interviewed in real time, wrapped his head around his head.
The 22-year-old Guerrero also ran in the fifth inning, leading the American League All-Stars to victory for eight consecutive years, making him the youngest MVP ever.