At the French Open, the next favorite was caught in the women's competition.
World number four Aryna Sabalenka from Belarus lost on Friday in the third round against Russian Anastasia Pavlyuchenkova 4-6, 6-2, 0: 6.
She has to wait for her breakthrough in a Grand Slam tournament.
Previously, the world number one Ashleigh Barty (resigned after injury) and Naomi Osaka (retreat after dispute over press boycott) had lost their chances.
Simona Halep, number three in the world, did not even start at the clay court classic due to an injury.
The German trio around Angelique Kerber (Kiel) failed in the first round.
Defending champion Iga Swiatek (Poland), last year's finalist Sofia Kenin (USA) and Jelena Switolina (Ukraine) have good prospects for the trophy.
Pavlyuchenkova will face Victoria Asarenka from Belarus in the round of 16, who clearly won 6-2, 6-2 against Madison Keys from the USA.
Arrested for alleged tampering
Meanwhile, Russian tennis player Jana Sisikowa was arrested by the Paris police on Friday for alleged manipulation in a doubles at the 2020 French Open.
This is reported by the AFP news agency.
The 26-year-old is said to have contributed to the set win of the Romanian opponents in doubles with her US partner Madison Brengle on September 30th last year through two intended double errors.
The Russian is currently 101st in the double world rankings and was eliminated in the first round of this year's French Open.
In professional tennis in recent years, athletes have been banned again and again because of their involvement in manipulation. For the most part, these were players who are hardly known internationally, who are placed far back in the world rankings and who only earn relatively little prize money.