The meeting, held in Sheffield, ended with a score of 3: 0 in favor of the guests.
The victory was brought to Arsenal by the double of Alexandre Lacazetta, who scored in the 33rd and 85th minutes, as well as the goal of Gabriel Martinelli, who scored in the 71st minute.
Arsenal are in ninth place in the Premier League standings with 45 points.
Sheffield, with 14 points, is in last, 20th place.
In other matches of the day, Newcastle United beat Burnley (2-1), while West Ham United beat Leicester City (3-2).
Earlier, Manchester United won a strong-willed victory over Tottenham in the Premier League match.