The meeting took place in Monaco and ended with a score of 2: 0.
As part of the home team, Stevan Jovetić and Kevin Volland distinguished themselves in the 76th and 90th minutes.
Moreover, two assists were given by Russian midfielder Alexander Golovin, who came on as a substitute in the 59th minute.
In the 30th minute, Monegasque striker Wissam Ben-Yedder failed to convert the penalty.
Monaco has 55 points and is fourth in the French Championship standings.
Brest (31) is in 13th position.
Earlier it was reported that Monaco defeated PSG in Ligue 1.