The match, which took place in Yaroslavl, ended in a victory for the hosts with a score of 3: 2 (OT).
Egor Korshkov, Teemu Pulkkinen and Atte Okhtamaa scored at Lokomotiv.
Reed Boucher and Sergei Tolchinsky scored among the guests.
Lokomotiv won their fourth victory in a row, and Avangard suffered their third defeat in a row.
Earlier, Metallurg defeated Spartak and advanced to the KHL playoffs.