The meeting took place in Lyon and ended in favor of the hosts - 4: 1.
Karl Toko Ekambi scored a brace for Lyon, as well as Memphis Depay and Ussem Auar (from the penalty spot).
Wissam Ben-Yedder scored the only goal from the 11-meter kick for the guests.
In the 89th minute, Lyon remained in the minority after Melven Bar was sent off.
Lyon scored 13 points and moved up to sixth in the French championship standings.
Monaco is in 12th position with 11 points.
Earlier it was reported that the doubles of Mbappe and Keane brought PSG a victory over Dijon in Ligue 1.