That gives Denmark 24 points and a 45-0 goal difference.
Italy is second in the group with 21 points, but with one match less played.
At home against Israel, it was 0-0 at half time, before star Pernille Harder made both 1-0 and 2-0 in the start of second for Denmark.
An own goal by Israel followed before Sofie Junge determined the final result.
In the last two rounds, a double meeting with the second Italy awaits, first away already on October 27 and then at home on December 1.
Two meetings that will decide which team can secure a European Championship place, even if the team that finishes second is also well placed.
All group winners are directly qualified for the European Championships, as are the top two runners-up. Other runners-up meet in playoff meetings.