Real Madrid ran into a painful defeat in La Liga on Saturday evening.
The reigning champion lost 0-1 at home to PhD candidate Cádiz.
Earlier in the day, Luis Suárez helped Atlético Madrid with a goal to a 0-2 victory on a visit to Celta de Vigo.
Real fell behind Cádiz after fifteen minutes.
Anthony Lozano passed Thibaut Courtois after Álvaro Negredo had prepared a cross with the head.
'De Koninklijke' then went in search of the equalizer, but hardly created any great opportunities.
Karim Benzema was the closest to a goal for the home team in the final phase with a bet on the post.
Despite the defeat, Real is in the lead in La Liga with ten points from five matches.
Cádiz is in second place with the same number of points, but has played one more match.
Joy at Atlético Madrid after Luis Suárez's opening goal. (Photo: ANP)
Joy at Atlético Madrid after Luis Suárez's opening goal.
Suárez helps Atlético to victory
In the Estadio de Balaídos, Suárez already scored after six minutes for Atlético Madrid against Celta de Vigo.
The Uruguayan found the goal on a pass from Manuel Sánchez with a shot to the right corner.
For Suárez, who came over from FC Barcelona this summer, it meant his third goal in the service of Atlético.
The attacker made a dream debut at the beginning of this month with two goals in the home game against Granada (6-1).
Yannick Carrasco secured the three points for Atlético deep in injury time, which climbs to fourth place with eight points from four games.
Granada celebrates the goal of Yangel Herrera. (Photo: ANP)
Granada celebrates the goal of Yangel Herrera.
Granada records a handsome victory over Seville
Earlier in the day, Granada booked a nice victory over Seville five days before the Europa League match with PSV: 1-0.
In Estadio Nuevo Los Cármenes, Venezuelan Yangel Herrera made the only goal eight minutes before the end.
At that time, the visitors played with a man less after two yellow cards just before half-time for Jordan.
Luuk de Jong started on the bench at Sevilla and came in halfway, while Karim Rekik and former Ajax player Nemanja Gudelj got no playing time.
Granada has an excellent start to the season and is currently in second place with ten points from five games.
Last season, Granada finished seventh, making its debut in Europe this season.
The club has already survived two preliminary rounds and a play-off in the Europa League.
PSV against Granada starts on Thursday at 6.55 pm in the Philips Stadium.
The other match in group E is between PAOK and Omonia.
FC Barcelona will play in La Liga later this Saturday.
The team of trainer Ronald Koeman will visit Getafe at 9 p.m. and Real Madrid will take on Cádiz at home at 6.30 p.m.
View the results, the program and the position in La Liga