The match at the Arthur Ash stadium lasted 4 hours 49 minutes and ended with a score of 7: 5, 6: 3, 5: 7, 4: 6, 6: 4.
The 23-year-old Muscovite made 14 aces and four double mistakes per match.
It was previously reported that Serena Williams was unable to win her 24th title in Grand Slam tournaments, losing to the 19-year-old Canadian Bianca Andreescu in the women's singles final.
RT led the text broadcast of the US Open men's singles final between Medvedev and Nadal.