Academician Zhang Boli revealed the secret of "Weiyang people": the absence of "yang" may be related to these factors

Academician Zhang Boli revealed the secret of "Weiyang people"——

Not having a "yang pass" may be related to these factors

　　People who have not passed the "sun" or those who have passed the "sun" should not relax their vigilance. They must insist on wearing masks scientifically, and pay more attention to personal protection when taking public transportation; during the Spring Festival, try to minimize visiting relatives and friends, Household gatherings; elderly patients with underlying diseases should be vaccinated and booster shots in time; the elderly, children, pregnant women and other key groups should minimize going out to avoid infection or re-infection.

　　——Zhang Boli, academician of the Chinese Academy of Engineering

　　【Answer to "epidemic"】

　　◎Our reporter Chen Xi

　　As the peaks of new crown virus infections in various places have passed, most people have already "Yangkang" or are on the way to "Yangkang".

However, there are also some people who go to work and live normally, and there is no "positive pass" from the beginning to the end.

　　According to many people's analysis, people who have no "yang" are in good health, have high immunity, and are not affected by viruses.

Some people also think that some people who feel that they have not been "positive" may have been infected, but their bodies are not abnormal.

So what is the truth?

　　Protection, vaccination or the key

　　"Aside from the genetic factors that are still under research and exploration, in theory, people who are healthier are less likely to be infected with the virus than those who are weak." Zhang Boli, an academician of the Chinese Academy of Engineering, said, "But we have observed in practice that due to the new coronavirus infection Whether they are infected with the new coronavirus has relatively little to do with the patient's physical factors, but has more to do with whether the protective measures taken are complete and whether the living habits are good."

　　If you look at the people who have not been "positive", most of their daily protection measures are in place. They can wear masks scientifically, wash their hands frequently, and even carry alcohol disinfection with them. Try to avoid contact with public objects and reduce the number of times they take off their masks; Regularity of life, balanced and healthy diet, regular life routes, avoid going to crowded places, no unnecessary contact with people, not only pay attention to prevention in the workplace, but also pay attention to disinfection inside the home.

　　"In addition, a considerable number of uninfected people have completed the vaccination of the new crown vaccine and booster shots, which have a certain preventive effect on the new crown virus and reduce the probability of infection." Zhang Boli said.

　　However, Zhang Boli also said that some people who have not been "positive" may have no obvious symptoms after infection, or they may not have undergone nucleic acid testing in time.

　　In an interview with the media on January 6, Li Tong, chief physician of the General Infection Department of Beijing You'an Hospital, pointed out that in this wave of epidemics, there may be many situations where there may be no "positive" in the body, including some people who did not show up after infection. Symptoms are asymptomatic infections.

Some people had been infected before this wave of the epidemic and had antibodies in their bodies, but they didn't notice it.

　　"Whether people who have not passed the 'sun' or those who have passed the 'sun' should not relax their vigilance." Zhang Boli reminded that we must insist on wearing masks scientifically, and pay more attention to personal protection when taking public transportation; Visiting relatives and friends, gatherings; elderly patients with underlying diseases should be vaccinated and booster shots in time; the elderly, children, pregnant women and other key groups should minimize going out to avoid infection or re-infection.

　　Are the genes of "Weiyang people" different?

　　"Current studies have indeed shown that different types of white blood cell surface antigens have different binding abilities to viruses. Some can quickly identify and clear viruses; others bind to viruses poorly, making it easier for viruses to replicate and spread in the body," Zhang Boli said. .

　　At present, a team of experts has found in the process of analyzing the experimental data of vaccine effectiveness that there is an association between the type of white blood cell surface antigen and the antibody response to the new crown vaccine and the risk of breakthrough infection, which shows that there are indeed some people who have specific genotypes that make them more vulnerable. It is not easy to be infected with the new coronavirus, such as the HLA-DQB1*06 allele.

　　A study of 1,076 COVID-19 vaccinators by the University of Oxford in the United Kingdom showed that during the epidemic of the original strain of the new crown and the alpha mutant strain, the chances of infection of people carrying this gene were 63% of those without it.

　　Conversely, there are some people who are more susceptible to infection

　　And genes that are more prone to severe diseases, such as the HLA-B*46:01 allele.

　　"The number of carriers of these genes in China and even in the world is relatively low, so the vast majority of people have neither susceptibility genes nor resistance genes." Zhang Boli said.

　　"In addition, the related regulation of white blood cells, interferon, and T cells, the mutation of the cell's ACE2 receptor or the congenital deficiency of the receptor may also affect the susceptibility of the new coronavirus, thereby reducing the probability of infection." Zhang Boli said, so some The ability of the population to remain negative cannot be completely determined to be due to genetic factors, and more experimental data and clinical data are still needed to support it.

　　Zhang Boli said that although the proportion of the "chosen son" is not large, it may be of great help to the research and development of future vaccines and drugs, and it also provides new ideas for future epidemic prevention and control strategies and directions. In-depth research on such "innately uninfected persons" needs to be paid attention to.

　　Related Links:

　　Facing new strains

　　Are people who have not had a "Yang health" more vulnerable than those with "Yang health"?

　　The Spring Festival is approaching and the flow of people will increase. Will people who have not been "Yangkang" be more vulnerable to new strains than those who are "Yangkang"?

　　Li Tong, chief physician of the Department of Infectious Diseases at Beijing You'an Hospital, once said that after being infected with the new coronavirus, the human body will produce antibodies.

Within 3 to 6 months after being infected with the new coronavirus, there is generally no re-infection.

However, the antibody level will gradually decline over time. At this time, whoever has strong immunity and the antibody level declines slowly will be "protected" for a longer period of time.

　　The severity of the disease after infection is related to the pathogenicity of the virus.

At present, the pathogenicity of the variant strains of Omicron is almost the same.

If a person who has been "positive" is infected again, the condition may be milder than the first infection.

People who have not had a "positive" infection will be infected to a similar degree to other people when they were infected for the first time.