The Soyuz rocket is in the launch pad for final preparations at the Russian Baikonur Cosmodrome in Kazakhstan.
Direction: the International Space Station.
The take-off is scheduled for 15:54.
NASA communicates this and also announces the crew.
On board an American astronaut and two Russian cosmonauts on a journey that marks a rare collaboration between Russia and the United States while the war continues in Ukraine.
NASA's Frank Rubio, Sergei Prokopyev and Dmitri Peteline of the Russian space agency Roscosmos will leave in the Soyuz spacecraft.
Rubio is the first American astronaut to travel to the ISS aboard a Russian craft since the beginning of the conflict in Ukraine on February 24.
The collaboration does not end there.
Anna Kikina, the only Russian cosmonaut on active duty, will travel to the orbital laboratory for the first time in early October aboard an American SpaceX Crew Dragon spacecraft.
She will be the fifth Russian professional cosmonaut to go to space and the first woman to fly aboard a spacecraft from billionaire Elon Musk's company.