Nasal spray neutralizing antibody drug test proves to prevent Omicron infection

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　　Science and Technology Daily, Chongqing, September 6th (Reporter Yong Li) Spray it to effectively prevent new crown virus infection.

On the 6th, Chongqing Medical University announced that the research led by the team of Professor Huang Ailong/Professor Jin Aishun found the antibody 58G6 with potent neutralizing activity against the new crown Omicron variant, and proved the intranasal administration method. Effectiveness of blocking the replication of Omicron mutants.

The related paper was recently published in the journal "Signal Transduction and Targeted Therapy".

　　"Every time the new coronavirus mutates once, a batch of neutralizing antibodies developed by many scientific research institutions around the world will fail, especially Omicron has more mutation sites, and not many of the original effective neutralizing antibodies survived. Fortunately, , the 58G6 neutralizing antibody we screened still maintains effective neutralizing activity." Jin Aishun introduced that the antibody 58G6 jointly identified by them and the Wuhan Institute of Virology team can be used alone to inhibit alpha, beta, gamma, delta, Austrian Pseudoviruses of various 2019-nCoV mutants of concern, such as Mikron, exhibit potent neutralizing ability, showing broad-spectrum neutralizing activity.

　　The researchers tested the neutralizing efficacy of the antibody in hamsters by intranasal administration.

The results showed that intranasal administration of 58G6 at a very low concentration (2 mg/kg) could effectively prevent hamsters from being infected with live Omicron virus.

　　The BA.2 submutant strain BA.2.12.1 found in New York, USA, and the BA.4 and BA.5 mutants found in South Africa are spreading rapidly.

Among the three mutant strains, there is also the key mutation L452 of Delta - it is this mutation site that gives Delta the transmission advantage.

The study found that the 58G6 antibody was also very effective against BA.1+L452R.

　　Huang Ailong introduced that the new coronavirus neutralizing antibody nasal spray drug (for prevention) developed by the school has completed the preparation of all preclinical research materials and has recently been submitted to the New Drug Evaluation Center of the State Food and Drug Administration.