The package is significantly less ambitious than what President Joe Biden proposed when he took office as president, but still includes $740 billion over ten years in investments mainly in climate measures and reduced medicine prices.
That the Senate passed the legislative package is seen as a great success for the president.
It passed by the narrowest possible majority, 51-50 in the House where Vice President Kamala Harris has the casting vote.
The reform package now moves on to the House of Representatives, where it is expected to be adopted.