The 21st and final stage, a 17.4 kilometer time trial, went to Matteo Sobrero (BikeExchange), Italian champion in the discipline.
In the final standings, Hindley, who runs for the German team Bora, precedes Ecuadorian Richard Carapaz, reigning Olympic champion and winner of the event in 2019.
Spaniard Mikel Landa takes third place ahead of Italian veteran Vincenzo Nibali (37), the double Giro winner who announced his retirement at the end of the season.
Hindley, who is 26, had finished second in the 2020 edition after losing the pink jersey on the final day in the Milan time trial.
This time, the Australian native of Perth presented himself with a 1 min 25 sec advantage over Carapaz, enough to parade in the arenas of Verona where the Ecuadorian had triumphed in 2019.
In the last lap, Hindley (15th) competed with Carapaz (10th) to whom he dropped only 7 seconds.
Australia has already won the Tour de France in 2011 through Cadel Evans, present Sunday in Verona.
On the other hand, no "Aussie" has yet registered his name on the Vuelta charts, the third grand tour of the cycling year.
In the Giro, Hindley is the second rider from his country to be on the final podium, after Cadel Evans still him (3rd in 2013).
If the uncertainty remained in place for the pink jersey until the last 3 kilometers of the 20th and penultimate stage, Saturday, on the slopes of Passo Fedaia in the Dolomites, Arnaud Démare secured the cyclamen jersey well before in the points classification for the second time in his career.
The Picard of the Groupama-FDJ team, who is not scheduled for the start of the Tour de France on July 1 in Copenhagen, won in three stages and asserted himself as the best sprinter in the Giro peloton despite the presence by Mark Cavendish (37 years old and co-holder of the Tour stage record).
Frenchman Arnaud Demare (c) wins the 13th stage of the Giro ahead of German Phil Bauhaus (g) and Briton Mark Cavendish, May 20, 2022 in Cuneo Luca Bettini AFP / Archives
The Dutchman Koen Bouwman, winner twice, brought back the blue jersey of best climber and the Spaniard Juan Pedro Lopez, at the top of the classification for ten days, the white jersey of best young person in front of the Colombian revelation Santiago Buitrago (22 years old). .
The joy of Dutchman Koen Bouwman, after winning the 19th stage of the Giro, disputed between Marano Lagunare and Santuario di Castelmonte, May 27, 2022 Marco ALPOZZI POOL / AFP
This 105th edition of the event created in 1909, very open at the start, was marked by its Grand Départ given for the first time in Hungary, where the Dutchman Mathieu van der Poel donned the first pink jersey.
Three other runners (Lopez, Carapaz, Hindley) then carried it before the Verona conclusion.
In the final time trial, Sobrero (25), who is good friends with world champion Filippo Ganna, beat Dutchman Thymen Arensman by 23 seconds to claim his first Giro success.
© 2022 AFP