Holder, the world champion seemed embarrassed for a few minutes when he left the field limping, without any particular shock that could explain the injury.
The contract for the Frenchman's second stint with the Red Devils ends in a few weeks.
He was replaced by Jesse Lingard, when the score was already 1-0 for Liverpool, after a goal from Luis Diaz in the 5th minute.
A few minutes later, Mohamed Salah added a second goal (2-0, 22nd) in a one-sided game.
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