Clashes broke out between Israeli security forces and Palestinians on Friday morning on the Temple Mount in Jerusalem, which is sacred to Jews and Muslims.
At least 90 Palestinians were injured after Israeli security forces used tear gas, according to the Red Crescent Palestinian Rescue Service.
According to police, after morning prayers ended, a violent clash erupted on the Temple Mount near Al-Aqsa Mosque, with rioters throwing stones and firing firecrackers.
Around 100 rioters were among around 12,000 believers.
Ramadan and Passover attract tens of thousands
Tens of thousands of Muslims were expected in Jerusalem's Old City for Friday prayers to pray on and around the Temple Mount (Al-Haram al-Sharif) during the Muslim month of fasting, Ramadan.
The Jewish Passover festival, which will also attract believers and visitors, also begins on Friday evening.
The Ministry of Tourism expects a total of 30,000 foreign tourists this week alone.
Al-Aqsa Mosque is the third holiest site in Islam.
In addition, despite a bloody wave of terror in Israel, thousands of Christians want to reenact Jesus' Way of the Cross in Jerusalem on Good Friday.
A massive police presence is expected, especially in the old town.
The security situation in Israel and the Palestinian territories is extremely tense: 14 people have been killed in four attacks in Israel in the past few weeks.
According to information from the AFP news agency, 21 people died on the Palestinian side.
Three dead in the West Bank
On Thursday, the Israeli army killed three people in its crackdown on Palestinian militants in the occupied West Bank.
According to the Palestinian Ministry of Health, two youths succumbed to injuries sustained in an Israeli attack in Jenin district.
A third Palestinian died a day after being "seriously injured by Israeli bullets" in clashes near Nablus.
The Israeli military said it would continue its "recent anti-terrorist activities."
Israel launched the large-scale operation last weekend, which is primarily focused on the area around Jenin in the north of the West Bank.
Israel's Prime Minister Naftali Bennett had announced tough action after a series of attacks.
According to the army, dozens of Palestinians attacked Israeli soldiers with explosive devices during the most recent Israeli operation.
The army then used live ammunition.
According to local information, one of the two youths killed was a brother of Aiham Kamamji, a member of Islamic Jihad.
He escaped from an Israeli high-security prison with five other prisoners in September, but was then arrested again.
Israel has arrested more than 200 Palestinians since early April, about half of them in the past six days, according to an aid organization for Palestinian prisoners.
On Thursday evening, the Israeli authorities announced that the border crossings to the occupied West Bank and Gaza Strip will be closed from Friday afternoon.
The closure will initially only last for two nights, but could be extended until the end of the eight-day Passover holiday.