The 23-year-old Argentinian, who reaches the last four of the event for the first time in his career and is competing in his first Masters 1000, will face the German Alexander Zverev (4th) or the Norwegian Casper Ruud (8th).
Sinner, who had saved several match points in his first two long and difficult rounds won against the Finn Emil Ruusuvuori and the Spaniard Pablo Carreno, could not finish this match, probably injured.
In Indian Wells, the Italian, ill, had to forfeit before his quarter-final against the Australian Nick Kyrgios, whom he also found on his way to Miami in the 8th, winning their duel.
His abandonment, after 23 minutes of play against Cerundolo, is the second of the day after that of the Spaniard Paula Badosa, who benefited the American Jessica Pegula, who also qualified for the semi-finals of the women's table.
For the Argentinian, semi-finalist in Rio de Janeiro in mid-February and whose best performance on the ATP circuit was a final at the Buenos Aires tournament last year (lost to his compatriot Diego Schwartzman), the dream career continues so.
In Miami, he has already triumphed over Frenchman Gaël Monfils (24th) on Monday and over American Frances Tiafoe (31st) in 8th.
For his entry into the running, he had benefited from another abandonment, that of the American Reilly Opelka (18th).
© 2022 AFP