Frenchman Christophe Laporte (Jumbo), third in the stage and very present at the front of the race, retained the leader's jersey.
Jakobsen overtook Belgian champion Wout van Aert to settle a first platoon of around forty elements.
In the general classification, Laporte is 5 seconds ahead of Van Aert and 11 seconds over the Slovenian Primoz Roglic, all three in the colors of the Jumbo team.
Frenchman Christophe Laporte, still the leader's yellow jersey, after his 3rd place in the 2nd stage of Paris-Nice, won by Dutchman Fabio Jakobsen, on March 7, 2022 in Orléans FRANCK FIFE AFP
The outgoing winner, the German Maximilian Schachmann, lost almost a minute and a half, as did the Portuguese Joao Almeida and the French Guillaume Martin, in a second group.
Jakobsen (25) won his sixth win of the season.
The Dutchman, who had never won in Paris-Nice before, was very seriously injured in 2019.
The European champion, the Italian Sonny Colbrelli, who suffers from bronchitis according to his Bahrain team, gave up taking the start in Auffargis (Yvelines).
Tuesday, the third stage presents a more hilly profile in its second half of the 190.8 kilometer long route between Vierzon (Cher) and Dun-le-Palestel (Creuse).
© 2022 AFP