Highly anticipated on the continental scene after stacking the goals in Italy, the young Vlahovic (22), who arrived this winter at Juve, is lined up alongside the Spaniard Alvaro Morata.
The two attackers will be surrounded on the wings by Weston McKennie and Juan Cuadrado, who beat Denis Zakaria to this position.
French international Adrien Rabiot will start in midfield with Manuel Locatelli.
In defence, captain Alex Sandro is expected to return to the left-back position after having served as a central last weekend against Torino.
Villarreal side, no surprise.
Frenchman Etienne Capoue returns to the starting XI after missing matches against Granada and Real Madrid due to muscle pain.
Note however that according to the official composition unveiled by UEFA, Samu Chukwueze has been integrated into the midfield with four with Capoue, Dani Parejo and Alberto Moreno, but he should evolve higher, and glued to the right sideline.
Villarreal: Rulli - Foyth, Albiol (cap.), P. Torres, Pedraza - Chukwueze, Capua, Parejo, Moreno - Lo Celso, Danjuma.
Coach: Unai Emery (ESP)
Juventus Turin: Szczesny - De Sciglio, Danilo, De Ligt, Alex Sandro (cap.) - Cuadrado, Locatelli, Rabiot, McKennie - Vlahovic, Morata.
Coach: Massimiliano Allegri (ITA)
Referee: Daniel Siebert (GER)
© 2022 AFP