China News Service, Shanghai, February 10 (Chen Jing Dongmei) Hashimoto's thyroiditis (HT) has a prevalence of more than 10% in the female population.
The reporter learned on the 10th that the research team of Professor Song Huaidong from the Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine revealed the molecular mechanism related to Hashimoto's thyroiditis patients who have long troubled people. The occurrence of clinical hypothyroidism provides a new idea.
It is reported that the research has just been published in the "Nature" sub-journal "Nature Communications".
According to Song Huaidong, so far, the medical community has little understanding of the mechanisms that lead to the destruction of thyroid cells in HT patients.
For these patients, there is currently no effective clinical treatment that can prevent the destruction of thyroid tissue and the occurrence of hypothyroidism; thyroid hormone replacement therapy can only be passively given to patients after hypothyroidism occurs.
However, even after treatment, the patient's peripheral blood thyroid hormone concentration has completely returned to normal, and about 25% of the patients still have symptoms of hypothyroidism.
The research of Song Huaidong's team further explored the pathogenesis of HT. They found that targeting and blocking the interaction of related cells is expected to block the infiltration of thyroid immune cells, thereby reducing the destruction of thyroid follicles and delaying the occurrence of hypothyroidism.
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