The US military says that it is on the verge of developing a comprehensive vaccine against all strains of Covid-19 of the Corona virus and its mutant such as Omicron and Delta, so what is the truth about that vaccine?
This news was reported by sources such as the Independent, businessinsider, Defense One, US ARMY and eurekalert.
The Independent said that the Walter Reed Institute for Research of the US Army - which is the largest biomedical research facility in the US Department of Defense - is close to achieving significant progress after two years of work on a vaccine that would work not only against existing strains and variants of Covid-19, But also against other potential species, according to Defense One.
What is the name of the US Army's anti-coronavirus vaccine?
The name of the vaccine is "Spike Ferritin Nanoparticle Covid-19", abbreviated as "SpFN".
Have Spike Ferritin Nanoparticle COVID-19 Vaccine Trials Been Conducted?
Animal experiments were conducted earlier this year with positive results.
Kavon Modgarad, director of the Infectious Diseases Branch at Walter Reed, said that the first phase of human trials was also conducted this year, with positive results.
What stage have the Spike Feritin nanoparticle COVID-19 vaccine trials reached?
The vaccine has not yet been subjected to Phase II and Phase III trials, and Phase I results are under review.
"It's very exciting to get to this point for our entire team and I think for the entire military as well," said Dr. Modgarad.
The institute said that human trials took longer than expected because the vaccine had to be tested on people who had not been vaccinated or infected with the Covid-19 virus to see its effectiveness.
"With Omicron, there is really no way to escape this virus. You will not be able to avoid it. So I think very soon either the whole world will be vaccinated or infected," Dr. Modgarad said.
"We need to evaluate it in a real-world environment and try to understand how the vaccine performs in much larger numbers of individuals who were already vaccinated with something else in the beginning...or were already sick," he added.
The Walter Reed Institute for Research has not yet revealed the name of its partner in the manufacturing process, who will handle the wider rollout of the vaccine.
The research institute said it focused on understanding how viruses mutate, not just the original emergence of the virus.
published results
A few days ago, the York Alert website - affiliated with the American Association for the Advancement of Science - published that a series of recently published results of preclinical studies show that the Spike Ferritin Nanoparticulate Covid-19 vaccine developed by researchers at the Walter Reed Institute Army Research not only elicits a strong immune response, but may also provide broad protection against worrisome variants of the coronavirus, as well as other coronaviruses.
Preclinical studies published in the journal Science Translational Medicine indicated that the spike ferritin nanoparticle COVID-19 vaccine protects non-human primates from disease caused by the original strain of SARS-CoV-2 (SARS-CoV-2). 2), and induces highly effective and widespread antibody responses against the major strains of COVID-19 of concern and SARS-CoV-1, which appeared in 2002.
How does Spike Ferritin Nanoparticle COVID-19 vaccine work?
The Spike Ferritin Nanoparticle Vaccine for COVID-19 is a "protein subunit nanoparticle vaccine platform", which means it delivers a portion of the virus to the immune system to trigger a protective response.
The COVID-19 spike ferritin nanoparticle consists of multiple coronavirus spike proteins bound to the surface of a "multifaceted ferritin nanoparticle", and researchers hypothesize that presenting multiple copies of the spike in an orderly fashion may be key to inducing A strong and widespread immune response.
Image showing histopathology and virus detection in the lungs of rhesus macaques immunized and not immunized with the Spikeferritin nanoparticle COVID-19 vaccine (Science Transitional Medicine)
The vaccine has advantages as a potential universal vaccine because it remains stable over a wide range of temperatures.
This will be especially useful in settings where extremely cold freezers are scarce.
The Spike Ferritin Nanoparticulate COVID-19 vaccine is formulated with an "adjuvant" substance called ALFQ.
This adjuvant is a component of the vaccine that helps activate the immune system and improve immune responses.
Clinical, preclinical and early stage studies have demonstrated that ALFQ is safe and highly effective as an adjuvant to the vaccine.
The Spike Ferritin Nanoparticle Covid-19 vaccine entered the first phase of human trials in April 2021. Early analyzes - expected to end this December - will provide insights into whether the power of the Spikeferritin nanoparticle Covid-19 will apply to humans.
The data will also allow researchers to compare the immune profile of the spike ferritin nanoparticle COVID-19 vaccine with other COVID-19 vaccines already licensed for emergency use.
“The threat from COVID-19 continues as it evolves, and eventually there will be other emerging disease threats,” said Dr. Nelson Michael, director of the Center for Infectious Disease Research at the Walter Reed Research Institute. “Our investment in developing a next-generation vaccine is an important step toward anticipating COVID-19.” and future disease threats.
What distinguishes the Spike Ferritin Nanoparticulate Covid-19 vaccine?
A report to "Business Insider" said that unlike most vaccines currently available, which use "mRNA" technology (mRNA) to stimulate the immune system, this vaccine works by injecting a molecule somewhat similar to a football with 24 faces.
Each face of the 'ball' will carry a little bit of a spiny protein that can stimulate the body to mount a protective immune response.
This allows scientists to attach spikes of multiple strains of coronavirus to different faces of the "ball", so the body can protect against many variables at once, rather than having to take a separate dose for each variable.