The young 18-year-old French international hopeful split from his first career double in C3, and was the main instigator of the Lyon overthrow after the Danish opener through Mikael Uhre (51).
Cherki first stole the ball from the feet of defender Blas Riveros to deceive the opposing goalkeeper (57), before being the author of an individual feat nine minutes later (66).
Islam Slimani, already double scorer against Sparta Prague (3-0) two weeks ago, added a third goal (76).
OL coach Peter Bosz had decided to rest the majority of his holders, including C3 top scorer Karl Toko Ekambi (6 goals), who entered the second half.
The Lyonnais, assured of finishing first in their group, will close the qualifications with the reception of the Glasgow Rangers on December 9, in their stadium.
© 2021 AFP