Visiting Wuhan National Human Genetic Resources Bank


  Explore the mystery of life at -196℃

  □ Changjiang Daily reporter Wu Tong and Hu Yihua, trainee reporter Hao Tianjiao

  The sample of human genetic resources is called the book of life.

On November 23, the Wuhan National Human Genetic Resource Bank (hereinafter referred to as the "Wuhan Sample Bank"), jointly constructed by Wuhan Institute of Biotechnology and Hubei Science and Technology Investment Group, was officially put into operation in the Innovation Park of Optics Valley Biocity.

  It is reported that the Wuhan sample bank is the first third-party sample resource bank in the country that has obtained the qualification for preservation after the "Regulations on the Management of Human Genetic Resources" was promulgated and implemented. It is also one of the five third-party sample banks approved for the preservation of human genetic resources in China. .

  At present, the sample library has the world's largest single automated ultra-low temperature storage equipment, which can realize 15 million tubes of sample storage, 30PB of information storage and comprehensive data processing capabilities.

  ■ The world's largest single storage capacity automated storage equipment

  The temperature of 29 gas phase liquid nitrogen tanks can reach -196℃

  On the afternoon of the 23rd, a reporter from Changjiang Daily walked into the Wuhan Sample Bank Building with a total construction area of ​​more than 60,000 square meters.

In the sample library preservation center on the first floor, the reporter saw through the thick glass that 29 gas-phase liquid nitrogen tanks were placed in an orderly manner.

  Zhang Hanrui, general manager of Wuhan sample library, introduced that the first phase of the sample library preservation center is equipped with the world's largest monomer storage automated storage equipment, with automated liquid nitrogen tanks, gas phase liquid nitrogen tanks and ultra-low temperature refrigerators, it can achieve a storage capacity of 15 million samples.

  "The temperature of the liquid nitrogen tank reaches -196°C, and the samples can be stored for a long time. Even after 10 or 20 years, the activity of the samples can still be maintained at 95% to 98% or more." Yang Zhongzheng, assistant general manager of Wuhan Sample Bank, said. The sample library can provide full temperature storage conditions including -80℃, -140℃ and -196℃, etc., according to the sample type and demand.

  The reporter saw on the periphery of the sample library building that a large liquid nitrogen tower was humming, continuously delivering liquid nitrogen to the sample library.

"The preservation of samples has strict environmental requirements and the temperature must be guaranteed." Yang Zhongzheng said that even if the liquid nitrogen tower fails, the sample preservation center is also equipped with artificial replenishers to meet the temporary emergency needs of sample storage.

 ■ Maintaining national biosecurity is of great significance

  Promote precision medicine to promote the progress of disease diagnosis and treatment

  "Biosafety and genetic safety are extremely important." Yang Zhongzheng said that from the perspective of human genetic resources samples, the disorderly flow and abuse of samples poses a threat to national biological and genetic security.

  Li Jiancheng, academician of the Chinese Academy of Engineering and vice president of Wuhan University, believes that human genetic resources are the key source of basic research and the core link of large sample verification and rapid realization of translational research. They have great scientific, social and economic value and are a major national strategic resource. It has important practical significance for maintaining national biosafety.

  "For the common people, the pursuit of disease prevention, the pursuit of longevity, the pursuit of precision treatment, precision pharmacy, it can be said that these ubiquitous life sciences are inseparable from the sample library." Academician of the Chinese Academy of Sciences, Wuhan Biotechnology Deng Zixin, dean of the Institute, said that the establishment of a human genetic resource bank is of great significance.

  Yao Shanglong, director of Hubei Provincial Anesthesiology Clinical Medicine Center and director of the Institute of Anesthesia and Critical Care Medicine of Union Hospital, specifically mentioned that compared with developed countries, China's anesthesia mortality rate is still at a relatively high level.

"With the sample library, it is possible to summarize and summarize the operation methods of anesthesia, establish an early warning model for organ damage, and reduce adverse effects through precise anesthesia."

  Zhang Hanrui introduced that Wuhan Sample Bank cooperated with Hubei Provincial Tumor Hospital to build a biological sample bank for malignant tumors such as colorectal cancer, breast cancer, and lung cancer. Based on the advancement of precision medicine, to discover the problems of existing diagnosis and treatment methods, and promote the progress of disease diagnosis and treatment.

  ■ The sample must be collected by a qualified medical institution

  Resource library is like "a piece of net" to build and share

  Where did the samples come from?

Zhang Hanrui said that samples of human genetic resources must be collected by qualified medical institutions such as hospitals.

  At the launching ceremony on the 23rd, Wuhan and Beijing Sample Bank and Tongji Hospital, Union Hospital, Wuhan University People's Hospital, Hubei Provincial Tumor Hospital and other medical institutions in Han signed strategic cooperation agreements.

  Data show that currently, there are 118 institutions in the country that have the qualifications for the preservation of human genetic resources, of which 75% are hospitals, lacking a large-scale platform.

  How to break through these sample "islands"?

Wuhan National Human Genetic Resources Bank can be said to be a net.

Academician Deng Zixin stated that the Wuhan sample bank uses the model of "1 main database, N sub-databases", which is equivalent to a center, allowing hospitals, universities, scientific research institutions, and enterprises to cooperate to build "storage, management, and management". Use the "three-in-one integrated platform" to connect the demander and the provider of resources, and each takes what they need, so that the resources can be used in all directions.

  ■ Use Huawei's most advanced solutions to ensure traceability

  Citizens can also apply for cell preservation through the hospital

  Yang Zhongzheng said: “All the cells and tissues of the human body can be stored and stored in the library. Citizens can also apply for the storage of human cells in the sample library through hospitals and other formal medical institutions.” For example, a family member suffers from some kind of genetic inheritance. Sexual diseases, while actively treating, can also apply to the hospital to store cells in the sample bank, "allowing scientific researchers to conduct in-depth research, develop new drugs, etc., to block this genetic disease."

  In Wuhan sample warehouse, all samples have strict standards and requirements for entering and exiting the warehouse.

"All samples must be obtained from qualified medical institutions, and the samples must be released from the library in accordance with the corresponding laws and regulations, while ensuring traceability." Yang Zhongzheng said that the sample library has established an operating mechanism to make all samples in an orderly manner. , Regular flow, to create a safety barrier.

  “The relevant data and information storage of the Wuhan sample library uses Huawei’s most advanced solutions to build a secure platform.” said Zhang Bin, general manager of Hubei Province of Huawei Cloud. In terms of data security, the Wuhan sample library is supported by Huawei’s technology. Create an intelligent supervision information platform to realize the traceability, mining integration, and open sharing of sample information throughout the chain.

  Faced with a large number of samples, how to correctly distinguish the information of each sample?

Yang Zhongzheng revealed to reporters that the sample is contained in a 1.4ml cryotube with a digital code and barcode printed on the tube body, and a QR code on the bottom. The three-code cryotube is equipped with automatic sample information scanning equipment and sample information management. The system will accurately ensure the one-to-one correspondence between samples and clinical information, ensuring traceability.