China News Service, Beijing, September 17 (Reporter Sun Zifa) Listening to beautiful music not only makes people happy physically and mentally, but may also have a certain therapeutic effect and potential for certain diseases.

  A new health research paper published in the open-access academic journal "Science Reports" under Springer Nature stated that the researchers found that listening to Mozart's D major sonata for two pianos (K448) for at least 30 seconds is associated with drug resistance. The frequency of epilepsy-related electrical activity spikes in the brain of patients with epilepsy is associated with a decrease.

The study also shows that the positive emotional response to K448 may help the treatment of patients with drug-resistant epilepsy.

  The paper pointed out that previous studies have shown that listening to K448 is related to the lower frequency of epilepsy-related electrical activity spikes in the brains of patients with epilepsy, but the effect of music duration on this correlation and its reasons are still unclear.

  The corresponding author of the paper, Robert Quon of Dartmouth Gesell College of Medicine in the United States, and colleagues used an electroencephalogram (EEG) to measure 16 adults with drug-resistant epilepsy listening to a series of music The electrical activity of the brain during the segment (15 to 90 seconds in length, including K448).

They found that listening to K448 for 30 to 90 seconds was associated with an average reduction in the number of electrical activity spikes related to brain epilepsy by 66.5%, but other music clips had no such effect.

At the same time, they found that this reduction is greatest in the left and right prefrontal cortex, which is involved in regulating emotional responses.

  The researchers also observed that when subjects heard the end of a long and repetitive section of K448, an electrical activity called theta wave increased in their prefrontal cortex.

Past research suggests that theta activity may be related to the positive emotional response to music.

  The author of the paper puts forward the hypothesis that just listening to K448 for 30 seconds may activate the brain's network related to the positive emotional response to music and regulated by the prefrontal lobe.

They believe that activating these networks may help reduce the electrical activity spikes associated with epilepsy in patients with drug-resistant epilepsy.

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