China News Service, July 5th (Reporter Chen Jing) Premature birth is one of the causes of death and disability among children under five.

Many surviving premature babies face the threat of lifelong disability.

  The reporter learned on the 5th that the team of Professor Sun Gang from the Reproductive Medicine Center of Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Shanghai Key Laboratory of Assisted Reproduction and Eugenics was the first to discover that the transcription enhancer binding protein (CEBPδ) may be involved in the activation of fetal membranes and the initiation of labor. Plays a key role.

They also discovered the specific mechanism that initiates labor.

  According to reports, how to control the start time of labor and reduce the incidence of preterm birth is very important.

Previous studies have found that delivery is controlled by a variety of factors, involving multiple processes such as fetal membrane activation, uterine contraction, and cervical softening. Glucocorticoid regeneration and prostaglandin synthesis are the key links in fetal membrane activation, but it is still unclear whether there is any Important transcription factors that simultaneously drive the above two key links.

As a result, clinically there has been a lack of effective means to prevent and treat preterm birth.

  It is reported that the research results of Professor Sun Gang's team were published online in the journal Clinical and Translational Medicine.

The latest research results on the initiation of childbirth will provide a new strategy for the prevention and treatment of preterm labor, and it is expected to provide new drug targets for blocking the initiation of labor, thereby providing new intervention methods for the prevention and treatment of preterm labor.

  The research team said that in the future, the research results are expected to be applied to the clinic, making a positive contribution to reducing the incidence of preterm birth and ensuring the safety and health of mothers and babies.

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