"Senator from the Lipetsk region Oleg Korolev submitted a written application for resignation for health reasons," Interfax quotes him as saying.
In accordance with the regulations, the application will be considered and submitted to the next meeting of the Federation Council, which is scheduled for June 23.
In May, it became known that Korolev had an accident in his car.
A video appeared on the Internet showing an SUV chaotically moving between lanes.
A man who looks like a politician is shown asleep at the wheel.
The media speculated that the senator was drunk, but he denied the accusations, explaining the incident with increased pressure and arrhythmia.
The governor of the Lipetsk region Igor Artamonov announced that he would send an appeal to the parliament to prosecute the official following the results of an inspection on the fact of violation of traffic rules.