• Vaccinated with AstraZeneca, 54 years old dies of thrombosis.

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  • Locatelli: "AstraZeneca to over 60. Under 60 vaccines to mRna"

  • Ema: "Do not give AstraZeneca vaccine to anyone with capillary leak syndrome"

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13 June 2021 The Johnson & Johnson Covid vaccine is an "adenovirus serum and it is preferable to reserve it for over 60s". Thus, in an interview with

La Stampa

, the president of the task force on vaccines of the European medicines agency (Ema), Marco Cavaleri. After the stop on Friday to administer the AstraZeneca vaccine to the under 60s,

Cavaleri also invites caution on the single-dose J&J

: "It gave less problems than AstraZeneca, even if it was used little. With one dose it is useful for some categories that are difficult to reach, but it remains adenovirus ". And the hypothesis is that with this type of serum "an immune reaction leading to thrombosis can be triggered. It has happened above all to young women, but not only".



Cavaleri does not condemn the AstraZeneca vaccine for which - he recalls - "accidents were very rare and after the first dose". However, answering a question, he states that "

banning AstraZeneca even for over 60s is an option that many countries, such as France and Germany, consider

in light of the increased availability of mRna vaccines". If this were the case, the serum of the Anglo-Swedish pharmaceutical giant would be completely excluded from the vaccination campaign.   



In short, now that there are fewer infections and more vaccines it is better to use something else. The context was different at the end of March: "At the time we had seen a probable very rare association between AstraZeneca and thrombosis, but our position was and is that in a pandemic context the risk-benefit balance remains favorable for all ages", he comments Cavaleri.



As for the

AstraZeneca Open Days, "we would have wished for a more cautious approach

with respect to the availability of other vaccines", underlines Cavaleri, who on the case of Camilla Canepa, the 18-year-old who died in Genoa about ten days after the first dose of AstraZeneca, says: "Already for the age it would have been better to use an mRna vaccine, then, even if the risk factors are not known, his health situation should have suggested prudence ".



Although the prosecutor investigating the death of the young woman will have to clarify various aspects of this, since the girl's family, through her lawyer, declared that the girl had no hereditary disease. 



On the

mix of vaccines

Cavaleri stresses that 

"it has already worked in the past, we do not expect safety problems

,

even if there are no large studies on it and careful monitoring will be needed

". Pericarditis after mRna vaccines "seem rare and light, they appear a week after the second dose, but we are talking to the US and Israel to find out more. By the beginning of July we will have more data".



On the Russian Sputnik vaccine "we have concluded site inspections and we are awaiting missing information. It is an adenovirus vaccine, of which we do not know what the future will be, although as Ema we will only rely on the risk-benefit ratio for the 'approval ", explains Cavaleri, but

Curevac will arrive first

,"

in September, it will be in mRna and will make up for the shortcomings of AstraZeneca

.

In the same period, Novavax will arrive,

a traditional vaccine that will also be useful ".



"The idea is that both the immunity of the recovered and that of the vaccinated last at least a year, even if for the elderly it could be lower. We will start with a recall for the fragile categories and then we will see if it will be necessary for everyone, too. based on the variants ", Cavaleri remarks, the Indian one" seems to be under control, but could generate worrying mutations. The vaccinated population will put pressure on the virus, which will try to escape. Not to mention that despite the efforts of the international community

, vaccination in the rest of the world proceeds slowly and for years there will be the risk of return variants.

Finally, there is the hypothesis that the virus continues to circulate even in the vaccinated. For this reason, pharmaceutical companies are working on vaccines that can be updated quickly and the EMA with more streamlined rules of approval. "

The vaccine in pill or patch, on the other hand, will arrive" not before 2023

". Finally, as regards the possibility that the Ema headquarters you arrive in Italy, "I don't know how the Milan appeal will end, but I don't think so. And as a Milanese I am very sorry ", he concludes