(Fighting New Coronary Pneumonia) Academician Gao Fu: New Coronary Vaccine Research and Development There are currently 7 routes in the world for 88 clinical trials
China News Service, Beijing, May 31 (Reporter Sun Zifa) Gao Fu, academician of the Chinese Academy of Sciences and director of the Chinese Center for Disease Control and Prevention, revealed that there are currently 7 new crown vaccine research and development technical routes in the world. There are now 272 candidate vaccines, of which 88 have entered Clinical Trials.
On the 30th, the Faculty of Chinese Academy of Sciences held an academic report meeting for all academicians of the seventh annual academic conference in Beijing. Gao Fu, an academician of the Faculty of Life Sciences and Medicine of the Chinese Academy of Sciences, gave a report on the topic of "Disease Prevention and Control and Healthy China: Asking for Answers to Science".
He said that different strategies for the prevention and control of the new crown pneumonia epidemic indicate that vaccines may be the ultimate solution.
At present, there are 7 vaccine research and development technology routes in the world, namely inactivated vaccines, live attenuated vaccines, recombinant protein vaccines, virus vector vaccines, virus-like particle vaccines, and nucleic acid vaccines (including DNA vaccines and RNA vaccines).
There are now 272 vaccine candidates worldwide, 88 of which are in clinical trials.
In the global new crown vaccine research and development, China currently has 3 inactivated vaccines and 1 adenovirus vector vaccine on the market conditionally, and 1 recombinant protein vaccine has been approved for emergency use.
These vaccines have shown good immunogenicity and safety.
Gao Fu introduced that his research team also screened two monoclonal antibodies CA1 and CB6, which can block the binding of the new coronavirus RBD protein to the hACE2 receptor and have strong neutralizing activity. Testing in the model found that CB6-LALA can inhibit the virus titer of the new coronavirus and reduce infection-related lung damage.
This is essential for the identification of viral RBD protein epitopes and will provide valuable information for the development of vaccines.
At the same time, the isolated monoclonal antibody CB6 with neutralizing effect may be a potential new coronary pneumonia treatment drug, and both China and the United States have entered clinical trials.
He pointed out that by sharing countries’ anti-epidemic experience and determining effective prevention and control strategies, it can help the international community to face the pandemic of the new crown together.
The team found that identifying and managing, as well as identifying and isolating close contacts, is a crucial containment measure, and it is vital to China's epidemic prevention path.
Although China has now almost stopped local transmission, it must continue to take strong suppression measures to prevent import-related cases from re-spreading in the community.
After the epidemic in Wuhan was brought under control in China, several small-scale epidemics occurred in Suifenhe in Heilongjiang, Shulan in Jilin, Beijing and Qingdao.
The Gaofu team traced the source of the virus through genome sequencing and found that many of the epidemics were caused by imported cold chain products that were contaminated by a higher load of new coronavirus through international marine fishery trade. The new coronavirus can be transmitted to cold chain loading and unloading through long-distance and close contact. Or processing workers caused it, and the new crown virus was isolated on the outer packaging of Qingdao cold chain products.
Gao Fu said that in the process of prevention and control of the new crown pneumonia epidemic, the public has a strong demand for popular science. Through relatively simple language, the scientific expression is clear, and the public needs are truly responded to, so that the public can receive correct and accurate information, and "isolate" the information epidemic. Disease is the direction that the majority of scientific researchers need to work together.
(Finish)