China News Service, April 27 (Reporter Chen Jing) Prostate cancer is the most common malignant tumor of the genitourinary system.
In recent years, the incidence of prostate cancer in China has increased rapidly.
The reporter learned on the 27th that Professor Xue Wei from the Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, and Professor Zhang Chunfu from the School of Biomedical Engineering, Shanghai Jiaotong University, have obtained new results in a joint research-the strategy of iron death triggered by exogenous heat is expected to be a treatment for prostate cancer Provide new ways.
According to reports, the exogenous heat-triggered iron death strategy has also been successfully implemented on kidney cancer and breast cancer cell lines. This treatment method may have broad-spectrum applicability, is expected to provide new ideas for tumor treatment, and has great practical application and transformation prospects.
According to reports, related results were published in the "American Chemical Society-Nano" magazine.
Among the newly diagnosed prostate cancer patients, more than half of the patients are locally advanced and metastatic.
What kind of treatment is adopted for these patients is the main challenge currently facing the medical profession.
Related results were published in the "American Chemical Society-Nano" magazine.
Research diagram
During the interview, the reporter learned that in recent years, inducing iron death of tumor cells has become a new strategy for anti-tumor therapy.
However, when the iron death inducer is applied by intravenous administration, indiscriminately attacking systemic cells may cause serious toxic side effects, which limits the specific choice and clinical application of drugs.
Researchers irradiate the tumor site with laser in situ, and use the 45°C heat generated by ferroferric oxide nanoparticles to trigger specific metabolic reprogramming and flexibly "manipulate" the "fate" of tumor cells, even if the tumor is effectively treated. It also avoids damage to normal tissues.
In the process, the researchers discovered relevant key regulatory factors, which is helpful to determine which type of death mode the tumor is more sensitive to, and provides mechanistic enlightenment and practical strategies for heat-induced iron death.
The researchers also verified that different heat application methods can achieve the same tumor suppression effect.
This means that clinically, magnetic thermal or ultrasonic hyperthermia may also trigger iron death treatment strategies, which greatly improves its clinical practicality and feasibility.
It is understood that this research is a cross-collaboration between the Department of Urology of Renji Hospital and the School of Biomedical Engineering of Jiaotong University. They leveraged their respective strengths and jointly applied nanotechnology and molecular biology technology to lay the foundation for the next step of in-depth cooperation and clinical transformation. A solid foundation.
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