China News Online, March 25th (Chen Jinghongxuan) In diabetic patients, a "dawn phenomenon" occurs in some patients, which means that such patients may have abnormal rhythms of insulin sensitivity.
The reporter learned on the 25th that medical experts from China and the United States worked together to reveal the mechanism by which the REV-ERB gene controls insulin to inhibit the circadian rhythm of liver gluconeogenesis.
Their research will help guide blood sugar control strategies for diabetic patients.
Related research papers completed by Ding Guolian's research group at Fudan University's Obstetrics and Gynecology Hospital/Reproductive and Development Research Institute, Sun Zheng's group at Baylor College of Medicine, and Chen Li's group at Shandong University Qilu Hospital were published online on the 25th in Nature.
It is understood that in clinical practice, some diabetic patients can control their blood sugar level at night or during most of the day, but they have high blood sugar at dawn, especially after breakfast.
Previously, scientists' studies on mice and humans have found that there is a circadian rhythm in insulin sensitivity in glucose metabolism.
However, there has not been a clear answer as to the physiological regulation mechanism of the circadian rhythm of insulin sensitivity.
In clinical studies, researchers used continuous dynamic blood glucose monitoring to divide patients with type 2 diabetes into a dawn phenomenon group and a non-dawn phenomenon group. The peripheral blood of the patients was collected at different time points to detect multiple biological clock-related genes in peripheral blood lymphocytes. Dynamic expression, and monitor the dynamic changes of serum insulin, melatonin and other hormone levels.
Researchers found that when there is no difference in sleep status, patients with dawn phenomenon do have significant differences in the expression rhythm of related nuclear receptors in the hypothalamus compared with patients without dawn phenomenon.
According to reports, the study reveals the regulatory mechanism of insulin sensitivity rhythm in glucose metabolism, not only explaining physiological phenomena, but also providing mechanism explanations and treatment suggestions for the "dawn phenomenon" that plagues diabetic patients.
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