China News Service, Kunming, January 19 (Reporter Hu Yuanhang) The Kunming Institute of Botany, Chinese Academy of Sciences released a research result on the 19th: Researchers found a novel structure with 7/6/6/6/5 rings in gooseberry fruit It may be used as a lead compound for the treatment of Alzheimer’s disease.
Gooseberry is a plant of the bitter wood family, which is born in low-altitude mountainous sparse forests.
Its root is also a traditional Chinese medicine, which has the effect of clearing away heat and detoxifying.
Alzheimer's disease is one of the most common neurodegenerative diseases that occurs in old age.
At present, there is still a lack of effective clinical cures or drugs for Alzheimer's disease.
Recently, Hao Xiaojiang's research group from the Phytochemical Biology team of the Kunming Institute of Botany, Chinese Academy of Sciences and Yao Yonggang's research group from the Kunming Institute of Zoology, Chinese Academy of Sciences discovered a novel structure of lemon with 7/6/6/6/5 ring system in gooseberry fruit Picrine compounds.
Researchers using Western blotting technology, enzyme-linked immunosorbent assay and cell transcriptome sequencing analysis found that the compound can act on multiple targets.
Not only can it inhibit the production of β-amyloid, a key factor in inducing Alzheimer's disease, but its inhibitory activity on the production of β-amyloid is also comparable to the positive control "gefibrozil" (a western medicine).
This is the first discovery that limonin compounds may be used as lead compounds for the treatment of Alzheimer's disease, providing new ideas for the research and development of new Alzheimer's disease drugs.
Relevant research results were published as one of the cover articles on Organic Letters, an authoritative journal of organic chemistry.
The reporter learned that Hao Xiaojiang's research group has long been committed to the discovery of plant-derived anti-Alzheimer's active substances.
Previously, they collaborated with Cai Jingxia's research group at the Kunming Institute of Zoology, Chinese Academy of Sciences to discover "Fincrotone", which has now entered Phase II clinical trials.
In addition, it also cooperated with the research group of Yang Chonglin from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and discovered the important active lead compound "ingenol ester" that can promote the production of lysosomes.