The American pharmacist firmly believes that the vaccine will tamper with the DNA and destroy the vaccine. Do
n't worry!
The new crown vaccine really can't change the human gene
For mRNA vaccines, the vaccine's nanoparticle carrier only sends the virus gene fragments into the cytoplasm, not the nucleus at all.
Even if the nucleus cannot be entered, how can there be a chance to integrate into the human genome?
—— Zhang Hongtao, Associate Professor of Research, Department of Pathology and Experimental Medicine, University of Pennsylvania School of Medicine
◎Our reporter Ma Aiping
On the last day of 2020, a pharmacist in Wisconsin, USA deliberately placed 500 doses of mRNA vaccine at room temperature for a long time, causing the vaccine to fail.
According to the investigator's report, the reason the pharmacist deliberately destroyed the vaccine was because he was worried that the vaccine carrying the new coronavirus gene fragment would cause harm by changing people's DNA.
Because before, a paper published by American researchers showed that after the addition of reverse transcriptase, the RNA of the new coronavirus can be reverse transcribed into DNA in in vitro cell experiments and integrated into the genes of human cells.
Will the RNA of the new coronavirus be integrated into human DNA?
Does vaccination of mRNA vaccine really cause genetic changes in the human body?
A reporter from Science and Technology Daily interviewed industry experts for this.
The genes of the new coronavirus will not be integrated into the human body
Viruses are divided into DNA viruses and RNA viruses based on their nucleic acid components.
According to reports, more than 200 viruses are known to infect humans.
Scientists have found that about 8% of the human genome today comes from viruses.
"Viruses with this ability are ancient retroviruses. Retroviruses will integrate nucleic acid into the host genome, and host cells will also replicate the viral nucleic acid as part of themselves and produce proteins to assemble new viruses. This process is equivalent to the virus hijacking the host and turning itself into a member of the host family. Hepatitis B virus is a DNA retrovirus, and it is usually difficult to remove this type of virus." Doctor of Biology, former Peking Union Medical College Professor Wang Chenguang said.
Does the new coronavirus have this ability?
"Although the new coronavirus has a certain similarity with one of the retroviruses (single-stranded RNA viruses), it is not a retrovirus, and the behavior of the two after infecting the host is essentially different. After the new coronavirus infects the host cell, It exists as a'foreign guest', but it is better disguised and treated by the host for food and drink-the viral nucleic acid can be replicated in the host cell, the protein can be expressed and produced, and finally the assembly of the virus particle is completed, but it does not Don't hijack the host." Wang Chenguang explained.
Zhang Hongtao, associate professor of research in the Department of Pathology and Experimental Medicine at the University of Pennsylvania School of Medicine, also pointed out in an interview with a reporter from Science and Technology Daily that the new coronavirus is an RNA virus, but not a "retro RNA virus", so the genes of the new coronavirus will not be integrated into human chromosomes. This is common sense.
Vaccination of mRNA vaccine will not cause genetic changes in the body
"Since the genes of the new coronavirus cannot change human genes, the mRNA vaccine made from the gene fragments of the new coronavirus S protein will not be integrated into the human body after vaccination." Zhang Hongtao said, "not to mention carrying it. The chromosomes of the human genome exist in the nucleus, and the nucleus is wrapped by a nuclear membrane. For mRNA vaccines, the nanoparticle carrier of the vaccine only sends the virus gene fragments into the cytoplasm, but does not enter the nucleus at all. Even the nucleus cannot enter, why Will there be a chance to integrate into the human genome? So, worrying about gene integration in mRNA vaccination is indeed a bit too much."
Regarding the conclusions of the papers published by American researchers mentioned above, Zhang Hongtao believes that this is just an in vitro experiment, which happened in a cell culture dish, not what actually happened in the human body.
In vitro experiments can be boldly explored as research, but in treatment and prevention, in vitro experiments cannot be simply regarded as a creed.
Wang Chenguang explained that the new coronavirus mRNA vaccine only contains a nucleic acid sequence that encodes a protein of the virus. Human cells then use their own components and viral mRNA templates to synthesize the protein.
The viral nucleic acid material is neither integrated into the human cell genome, nor is it replicated and amplified in the cell.
Not only did the cells not be hijacked by the virus, but instead used the proteins they synthesized together to train a group of "mercenaries", and then used the "mercenaries" to prevent the invading enemy-the new crown virus.