The explosion on Friday morning (local time) in downtown Nashville was caused by a bomb in a motor home, according to police.
The bomb turned the area into great havoc and three people were slightly injured.
Shortly after the incident, the authorities informed local media that this may have been a deliberate action.
Officers approached a report of a shooting at 6:00 am and found a suspicious vehicle upon arrival.
A message could be heard from the camper that a bomb would go off within fifteen minutes.
Images from surveillance cameras can be heard for minutes on end calling for evacuation.
According to a police chief, it was warned that the bomb would explode within 15 minutes.
The alerted explosives disposal service was too late to dismantle the bomb.
The explosion turned the street into havoc and collapsed building facades.
Photos show how debris is on the road and windows have fallen.
Camera captures moment of explosion in Nashville
FBI investigating explosion
The federal police department FBI is investigating the incident.
No arrests have yet been made.
The Nashville mayor has called on people to stay out of the area.
Car bombs in the United States are uncommon.
The most famous car bomb attack was Timothy McVeigh's bombing in Oklahoma City in 1995, killing 168 people, including nineteen children