Mike Pence's vaccination was broadcast live on television.
The US vice president said he was "happy to have received this safe and effective vaccine."
For his part, President-elect Joe Biden must be vaccinated on Monday, while Donald Trump has given him no indication.
US Vice President Mike Pence was given Pfizer / BioNTech's coronavirus vaccine on Friday, an injection broadcast live on television as the United States prepares to authorize a second vaccine.
Vice President Mike Pence, second Lady Karen Pence and Surgeon General Jerome Adams just received their first doses of the Pfizer coronavirus vaccine.
https://t.co/GonWFGXbArpic.twitter.com/DS4U8MYwLs
- CNN (@CNN) December 18, 2020
Mike Pence said he was "happy to have received this safe and effective vaccine".
"I didn't feel anything," he added.
"We are gathered here this morning to build confidence" in this vaccine, said Mike Pence, who was vaccinated along with his wife.
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The US vice-president, responsible for coordinating the fight against the pandemic in recent months from the White House, has been vaccinated as Europe sees several of its leaders placed in quarantine before Christmas.
Nancy Pelosi was also vaccinated
The leader of the Democrats in the US Congress was also vaccinated on Friday.
"Today, with confidence in science (...), I received the vaccine against the Covid-19", tweeted Nancy Pelosi, 80, posting pictures of her receiving the injection.
Today, with confidence in science & at the direction of the Office of the Attending Physician, I received the COVID-19 vaccine.
As the vaccine is being distributed, we must all continue mask wearing, social distancing & other science-based steps to save lives & crush the virus.
pic.twitter.com/tijVCSnJd7
- Nancy Pelosi (@SpeakerPelosi) December 18, 2020
"While the vaccine is being distributed, we must all continue to wear masks," said the Speaker of the House of Representatives.
Joe Biden's vaccination scheduled for Monday
President-elect Joe Biden is due to be vaccinated on Monday, also live on television.
As for Donald Trump, who was infected with the virus earlier this year, he has so far given no indication on when he might also bow to the exercise.
"The president is ready to be vaccinated and will do so as soon as his medical team deems it appropriate," said spokesman Kayleigh McEnany this week.
The United States is preparing to authorize a second vaccine against the disease.
A committee of experts ruled Thursday in favor of the emergency authorization of Moderna, which augurs well for a positive decision from the US Medicines Agency (FDA) expected on Friday.