An experienced Democrat, Ron Klain will be Joe Biden's chief of staff in the White House from next January.
This lawyer and senior official had already accompanied the victorious candidate for the same post at the start of Barack Obama's first term in 2009.
Joe Biden on Wednesday chose Ron Klain, a veteran Democrat, to be his White House chief of staff, the US president-elect said in a statement announcing his first-ever appointment.
"Ron Klain's long and diverse experience and his ability to work with people from all political backgrounds is precisely what I need for a White House chief of staff as we face this time of crisis and bring our country together again, "said the president-elect.
Key man for Ebola in the White House
"Ron has been invaluable to me over the many years we have worked together," added Joe Biden of the one who served as his first chief of staff when he was vice president, from 2009 .
Ron Klain, 59, also worked with Joe Biden when he was chairman of the Senate Judiciary Committee.
He was then the Chief of Staff to Vice President Al Gore.
Under the presidency of Barack Obama, Ron Klain coordinated the White House response to the Ebola crisis in 2014.
Praise from Democrats
In the same press release released by the president-elect's transition team, Ron Klain said it was "the honor of a lifetime" to be appointed to this post.
"I look forward to helping him and the Vice President-Elect bring together a talented and diverse team to work in the White House, to embark on their ambitious agenda for change, and seek to bridge the divisions in our country, ”he added.
Ron Klain's choice garnered praise from Democrats, such as Senator Elizabeth Warren, who called Ron Klain's appointment a "super pick" because he "understands the scale of the health and economic crisis and he has the 'experience to lead this next administration ".
Conservative radio host Hugh Hewitt called Ron Klain a "formidable choice for president-elect" and a "serious" pandemic risk analyst.