China News Service, September 4th (Chen Jing and Wang Juliang) At 4 pm Beijing time on the 4th, a remote consultation between Chinese and Japanese doctors is being held at the National Children's Medical Center and Fudan University Pediatric Hospital Remote Consultation Center.

Chinese Pediatric Gastroenterology, Surgery, and Hematology experts were invited to discuss with Japanese pediatricians the condition of very early-onset inflammatory bowel disease in a girl who was only two months old to determine the next diagnosis and treatment plan.

　　Niuniu (pseudonym), who is only two months old, is the third daughter of Mr. Li and his wife who have lived in Japan for 20 years.

However, on the second day of her life, she had repeated fever, diarrhea, and bloodshot mucus in her stool.

After being admitted to the neonatal intensive care unit of a general hospital in Osaka, Niuniu continued to develop severe oral ulcers, extensive skin erythema, and high body temperature... the condition continued to develop.

On July 16, Niuniu was transferred to the Affiliated Hospital of Kyoto University School of Medicine, Japan, but the curative effect was not good. The child still had repeated diarrhea and intermittent fever.

Doctors from the two countries conducted detailed discussions online.

Photo by Wang Juliang

　　High-throughput gene sequencing showed that Niuniu is an extremely early-onset inflammatory bowel disease caused by related gene mutations.

The gastroenterologist of the diagnosis and treatment team performed colonoscopy on the child and found that there were many ulcers in the intestines, some of which were deep and large.

It is reported that very early-onset inflammatory bowel disease refers to children with inflammatory bowel disease under 6 years old, including newborns, infants and young children.

Currently, there are more than 70 pathogenic single gene mutations associated with the occurrence of very early-onset inflammatory bowel disease.

　　It is reported that Japan has reported a total of 4 cases similar to Niuniu, including 2 deaths.

Doctors at the Kyoto University Hospital felt that their experience in treating the disease was limited, and the diagnosis and treatment of the child was in trouble.

The parents of the children want to return to their home country for treatment, but due to factors such as the new crown pneumonia epidemic, they are unable to do so.

　　Japanese doctors and parents of children learned from the Internet that the National Children's Medical Center and the Children's Inflammatory Bowel Disease Multidisciplinary Team of the Children's Hospital of Fudan University have considerable experience and achievements in drug intervention for related diseases and hematopoietic stem cell transplantation.

They asked the Children's Hospital of Fudan University for help, hoping to organize a remote international consultation.

　　In 2015, the children's inflammatory bowel disease multidisciplinary team affiliated to Fudan University took the lead in diagnosing children with inflammatory bowel disease caused by mutations in related genes and successfully performed cord blood stem cell transplantation.

By the end of August 2020, the Children's Hospital Affiliated to Fudan University has admitted more than 100 children of this type, of which more than 60 have received hematopoietic stem cell transplantation, and most of them have recovered well.

In recent years, Chinese experts have published high-quality academic papers in internationally renowned academic journals, attracting the attention of foreign colleagues.

　　During the remote consultation that day, Professor Ying Huang of the Department of Gastroenterology, Professor Dong Kuoran of General Surgery, and Deputy Director Qian Xiaowen of the Department of Hematology had a detailed discussion online with a number of doctors from the Department of Pediatrics of the Affiliated Hospital of Kyoto University Medical School.

After the consultation, the Chinese and Japanese doctors reached a preliminary agreement on the treatment plan.

The Pediatric Hospital of Fudan University will provide support and help for Niuniu's follow-up treatment.

　　(Finish)